Variability of response to antiplatelet therapy
نویسندگان
چکیده
منابع مشابه
The clinical relevance of response variability to antiplatelet therapy.
Interindividual variability in the pharmacological response to antiplatelet drugs has been reported in some studies. Suboptimal response to aspirin, as determined by specific tests (serum thromboxane B(2)), appears to be rare and in most cases is caused by poor compliance. In contrast, studies using specific tests to measure the pharmacological effect of clopidogrel showed a wide variability of...
متن کاملGenetic and acquired determinants of individual variability of response to antiplatelet drugs.
Individual heterogeneity in responsiveness to antiplatelet agents may be due to either inherited or acquired factors. These potential variables include genetic polymorphisms in platelet proteins targeted by the drugs, differences in their pharmacokinetics, drug or other environmental interactions, and the baseline state of platelet function before initiation of treatment. With regard to the lat...
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In the past few years, it has been realized that cardiovascular events under dual antiplatelet therapy (DAPT) might be associated with a poor response to clopidogrel. Based on different platelet function assays, 20–25% of clopidogrel-treated patients undergoing percutaneous coronary intervention (PCI) and coronary stenting have been defined as poor responders and were prone to an increased risk...
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Following the introduction of transcatheter aortic valve im-plantation (TAVI), it is now possible to treat elderly patients with severe aortic stenosis and a high surgical risk. This advancement in interventional cardiology has led to increased survival, health status and quality of life. However, as with many invasive interventional procedures, TAVI is associated with the risk of cerebral embo...
متن کاملIn response to What is the optimal perioperative management of antiplatelet therapy?
BACKGROUND A significant proportion of patients undergoing otolaryngological surgery take antiplatelet therapy for a variety of conditions, including coronary artery disease and angina; following cardiac procedures, stroke, or transient ischemic attacks; and peripheral vascular disease. However, continuation of antiplatelet therapy may lead to increased risk of bleeding, whereas discontinuation...
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2008
ISSN: 1554-2815,1520-1554
DOI: 10.1093/eurheartj/sum080